{"refrec":{"BRefID":70480,"RR":"<b>Miura, C.; Takahashi, N.; Michino, F.; Miura, T.</b> (2005). The effect of para-nonylphenol on Japanese eel (<i>Anguilla japonica</i>) spermatogenesis in vitro. <i>Aquat. Toxicol. 71(2)</i>: 133-141. <a href=\"https://dx.doi.org/10.1016/j.aquatox.2004.10.015\" target=\"_blank\">https://dx.doi.org/10.1016/j.aquatox.2004.10.015</a>","BEntID":66540,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Aquat. Toxicol. 71(2)</i>: 133-141. <a href=\"https://dx.doi.org/10.1016/j.aquatox.2004.10.015\" target=\"_blank\">https://dx.doi.org/10.1016/j.aquatox.2004.10.015</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Miura, C.; Takahashi, N.; Michino, F.; Miura, T.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Miura, C. <i>et al.</i>","Englishabstract":"Endocrine disrupters have been recognized to interfere with endocrine systems that regulate reproduction, for example, by mimicking or inhibiting the action of endogenous sex steroid hormones including estradiol-17β (E2). In the present study, we examined the effect of an endocrine disrupter, para-nonylphenol (p-NP) on spermatogenesis, and compared it with the action of E2, using an eel testicular organ culture system. <i>p</i>-NP alone stimulated early spermatogonial renewal in the same manner as E2. Neither induced further progress in spermatogenesis. In the presence of 11-ketotestosterone (11-KT), the major androgen in teleosts, <i>p</i>-NP did not prevent the 11-KT-induced progress in spermatogenesis. However, this treatment enlarged the Sertoli cells. Electron microscopic observation revealed that enlarged Sertoli cells contained well-developed organelles. Moreover, the proportion of germ cells appeared to have decreased as a result of Sertoli cell hypertrophy. These results clearly show that p-NP has an effect on Sertoli cells in the presence of an androgen (11-KT), potentially disturbing 11-KT-induced spermatogenesis.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"The effect of para-nonylphenol on Japanese eel (<i>Anguilla japonica</i>) spermatogenesis in vitro","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-27 01:31:24.901155","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"nonylphenol; Japanese eel; spermatogenesis; endocrine disruption;11-ketotestosterone; testis; sertoli cells; estradiol-17 beta","OtherDescriptors":"Nonylphenol; Japanese eel; Spermatogenesis; Endocrine disruption; 11-Ketotestosterone; Testis; Sertoli cells; Estradiol-17β","Notes":null,"AnaPub":2005,"MonPub":null,"DateUpdate":"2020-10-06","DateCreate":"2005-02-10","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000226558400003","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.aquatox.2004.10.015"},"refs":null,"anarec":{"AnaID":70480,"PubliDate":2005,"Pagination":"133-141","XtraPublOfAnaID":null,"ISBN":null,"Volume":"71","Issue":"2","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42203,"SerRR":"Aquatic Toxicology. 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