{"refrec":{"BRefID":74761,"RR":"<b>Defoirdt, T.; Bossier, P.; Sorgeloos, P.; Verstraete, W.</b> (2005). The impact of mutations in the quorum sensing systems of <i>Aeromonas hydrophila, Vibrio anguillarum</i> and <i>Vibrio harveyi</i> on their virulence towards gnotobiotically cultured <i>Artemia franciscana</i>. <i>Environ. Microbiol. 7(8)</i>: 1239-1247. <a href=\"https://dx.doi.org/10.1111/j.1462-2920.2005.00807.x\" target=\"_blank\">https://dx.doi.org/10.1111/j.1462-2920.2005.00807.x</a>","BEntID":70433,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Environ. Microbiol. 7(8)</i>: 1239-1247. <a href=\"https://dx.doi.org/10.1111/j.1462-2920.2005.00807.x\" target=\"_blank\">https://dx.doi.org/10.1111/j.1462-2920.2005.00807.x</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Defoirdt, T.; Bossier, P.; Sorgeloos, P.; Verstraete, W.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Defoirdt, T. <i>et al.</i>","Englishabstract":"Disruption of quorum sensing, bacterial cell-to-cell communication by means of small signal molecules, has been suggested as a new anti-infective strategy for aquaculture. However, data about the impact of quorum sensing on the virulence of aquatic pathogens are scarce. In this study, a model system using gnotobiotically cultured <i>Artemia franciscana</i> was developed in order to determine the impact of mutations in the quorum sensing systems of<i>Aeromonas hydrophila</i>, <i>Vibrio anguillarum</i> and <i>V. harveyi</i> on their virulence. Mutations in the autoinducer 2 (AI-2) synthase gene luxS, the A<i>V. harvey</i> abolished virulence of the strain towards <i>Artemia</i>. Moreover, the addition of an exogenous source of AI-2 could restore the virulence of an AI-2 non-producing mutant. In contr<i>V. harveyi</i> system or the quorum sensing systems of <i>Ae. Hydrophila</i> and <i>V. anguillarum</i> had an impact on virulence of these bacteria towards <i>Artemia</i>. Our results indicate that disruption of quorum sensing could be a good alternative strategy to combat infections caused by <i>V. harvey</i>.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"The impact of mutations in the quorum sensing systems of <i>Aeromonas hydrophila, Vibrio anguillarum</i> and <i>Vibrio harveyi</i> on their virulence towards gnotobiotically cultured <i>Artemia franciscana</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-10 01:31:28.769917","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2005,"MonPub":null,"DateUpdate":"2005-07-14","DateCreate":"2005-07-14","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000230336500018","VABBcode":null,"OpenAcc":0,"DOI":"10.1111/j.1462-2920.2005.00807.x"},"refs":null,"anarec":{"AnaID":74761,"PubliDate":2005,"Pagination":"1239-1247","XtraPublOfAnaID":null,"ISBN":null,"Volume":"7","Issue":"8","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":59926,"SerRR":"Environmental Microbiology. 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