{"refrec":{"BRefID":75866,"RR":"<b>Yamakoshi, K.; Shishido, Y.; Shimoda, N.</b> (2005). Generation of aberrant transcripts of and free DNA ends in zebrafish <i>no tail</i> gene. <i>Mar. Biotechnol. 7(3)</i>: 163-172","BEntID":71536,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":null,"RefStringPartII":". <i>Mar. Biotechnol. 7(3)</i>: 163-172","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Yamakoshi, K.; Shishido, Y.; Shimoda, N.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Yamakoshi, K.; Shishido, Y.; Shimoda, N.","Englishabstract":"The zebrafish <i>no tail</i> gene (<i>ntl</i>) is indispensable for the formation of the notochord and the tail structure. In a wild-type zebrafish population, we occasionally observed adult zebrafish with a narrow or no tailfin. This led us to examine the hypothesis that the activity of <i>ntl</i> was somehow genetically unstable. Here we present two findings regarding the gene. First, approximately 3% of <i>ntl</i> transcripts were aberrant; most of them carried deletions at various positions. Second, free, DNA double-stranded ends (DSEs) were formed at an AT dinucleotide repeat in <i>ntl</i>. DSEs were also generated in another zebrafish gene, <i>noggin2</i> (<i>nog2</i>). DSEs in <i>ntl</i> and <i>nog2</i> had common characteristics, which suggested that the AT repeats in these genes elicited DSEs by blocking progression of the replication.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Generation of aberrant transcripts of and free DNA ends in zebrafish <i>no tail</i> gene","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2005,"MonPub":null,"DateUpdate":"2005-09-05","DateCreate":"2005-08-25","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":null,"VABBcode":null,"OpenAcc":1},"refs":null,"anarec":{"AnaID":75866,"PubliDate":2005,"Pagination":"163-172","XtraPublOfAnaID":null,"ISBN":null,"Volume":"7","Issue":"3","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":45426,"SerRR":"Marine Biotechnology. Springer-Verlag: New York.  ISSN 1436-2228; e-ISSN 1436-2236","StandardTitleSer":"Marine Biotechnology","ISSN":"1436-2228","AbbrevSer":"Mar. Biotechnol.","StandardTitleMon":null,"StartPage":163,"Pages":10,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Yamakoshi","Firstname":"Kimi","Initials":"K.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":71536,"AutID":54924,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Shishido","Firstname":"Yuji","Initials":"Y.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":71536,"AutID":54925,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Shimoda","Firstname":"Nobuyoshi","Initials":"N.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":71536,"AutID":54928,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":73151,"LibID":36,"BRefID":75866,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":1,"ShelfLocCode":"73151","RFID":null,"PaidValue":null,"Medium":"Server","Description":"VLIZ Open Access","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Open access","URL":null,"ClassifID":53,"Classification":"Open access","ReqLink":null,"ClassifTypID":1,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":null,"InternalReq":0,"LoggedInReq":0,"Disclaimer":null,"DutchDisclaimer":null,"FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"Springer-Verlag","City":"New York"}],"MONpubls":null,"pictures":[],"thestermsPath":[{"ThesaurusTerm":"Zebrafish","ThestID":72127,"Acronym":"CSA","ThesTermPath":"Zebrafish"}],"thestermsASFA":[{"ThesaurusTerm":"Zebrafish"}],"taxtermsASFA":null,"geotermsASFA":null,"collections":null,"conf":null,"proj":null,"Physdatasets":null,"spcols":null,"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":71536,"AbstractFlag":-1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":71536,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":null,"thesterms":[{"ThesaurusTerm":"Zebrafish","ThestID":72127,"Acronym":"CSA","ThesTypID":2,"ThesType":"CSA Technology Research Database Master Thesaurus"}],"taxterms":null,"geoterms":null,"othterms":[{"OtherTerm":"Double-stranded end","OthtID":13400},{"OtherTerm":"Microsatellite repeat","OthtID":13403}],"asfacodes":null,"asfa2codes":null,"thestermsFRIS":[{"ThesaurusTerm":"Zebrafish","DutchTerm":null,"ThestID":72127,"Acronym":"CSA","ThesTypID":2,"ThesType":"CSA Technology Research Database Master Thesaurus"}],"taxtermsFRIS":null,"geotermsFRIS":null,"othtermsFRIS":[{"OtherTerm":"Double-stranded end","DutchTerm":null,"OthtID":13400},{"OtherTerm":"Microsatellite repeat","DutchTerm":null,"OthtID":13403}],"resmessage":"","complete":1,"sessions":{"newSesName":"Chisala, Chilekwa, C.","newSesDate":{"date":"2005-08-25 12:31:39.150000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Haspeslagh, Jan, J.","updSesDate":{"date":"2005-09-05 09:33:30.240000","timezone_type":3,"timezone":"Europe/Brussels"}}}