{"refrec":{"BRefID":75926,"RR":"<b>Thakur, A.N.; Thakur, N.L.; Indap, M.M.; Pandit, R.A.; Datar, V.V.; Müller, W.E.G.</b> (2005). Antiangiogenic, antimicrobial, and cytotoxic potential of sponge-associated bacteria. <i>Mar. Biotechnol. 7(3)</i>: 245-252","BEntID":71595,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":null,"RefStringPartII":". <i>Mar. Biotechnol. 7(3)</i>: 245-252","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Thakur, A.N.; Thakur, N.L.; Indap, M.M.; Pandit, R.A.; Datar, V.V.; Müller, W.E.G.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Thakur, A.N. <i>et al.</i>","Englishabstract":"The bacteria associated with marine invertebrates are a rich source of bioactive metabolites. In the present study bacteria associated with the sponge <i>Suberites domuncula</i> and its primmorphs (3-dimensional aggregates containing proliferating cells) were isolated and cultured. These bacteria were extracted, and the extracts were assayed for antiangiogenic, hemolytic, antimicrobial, and cytotoxic activities. Our studies revealed that extract obtained from the bacterium (PB2) isolated from sponge primmorphs is a potent angiogenesis inhibitor. In the chick chorio-allantoic membrane (CAM) assay, it showed 50% activity at 5 &#x3bc;g ml<sup>&#x2212;1</sup> and 100% activity at 10 and 20 &#x3bc;g ml<sup>&#x2212;1</sup> concentrations. Extracts obtained from 5 bacterial strains isolated from sponge and its primmorphs showed hemolytic activity. The sponge-associated bacteria belonging to the &#x3b1; subdivision of <i>Proteobacteria</i> and the primmorph-associated bacterium identified as a possible novel <i>Pseudomonas</i> sp. displayed remarkable antimicrobial activity. It is important to note that these bacterial extracts were strongly active against multidrug-resistant clinical strains such as <i>Staphylococcus aureus</i> and <i>Staphylococcus epidermidis</i>, isolated from hospital patients. The bacterial extracts having antimicrobial activity also showed cytotoxicity against HeLa and PC12 cells. In summary, this investigation explores the importance of sponge-associated bacteria as a valuable resource for the discovery of novel bioactive molecules.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Antiangiogenic, antimicrobial, and cytotoxic potential of sponge-associated bacteria","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:01.897972","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2005,"MonPub":null,"DateUpdate":"2005-09-05","DateCreate":"2005-08-29","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000230431000013","VABBcode":null,"OpenAcc":1},"refs":null,"anarec":{"AnaID":75926,"PubliDate":2005,"Pagination":"245-252","XtraPublOfAnaID":null,"ISBN":null,"Volume":"7","Issue":"3","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":45426,"SerRR":"Marine Biotechnology. Springer-Verlag: New York.  ISSN 1436-2228; e-ISSN 1436-2236","StandardTitleSer":"Marine Biotechnology","ISSN":"1436-2228","AbbrevSer":"Mar. Biotechnol.","StandardTitleMon":null,"StartPage":245,"Pages":8,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Thakur","Firstname":"Archana","Initials":"A.N.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":71595,"AutID":54979,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Thakur","Firstname":"Narsinh","Initials":"N.L.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":71595,"AutID":54980,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Indap","Firstname":"Madhavi","Initials":"M.M.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":71595,"AutID":54981,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Pandit","Firstname":"Reena","Initials":"R.A.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":71595,"AutID":54982,"OrderNr":4,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Datar","Firstname":"Vrushali","Initials":"V.V.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":71595,"AutID":54983,"OrderNr":5,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Müller","Firstname":"Werner","Initials":"W.E.G.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":71595,"AutID":33557,"OrderNr":6,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":73216,"LibID":36,"BRefID":75926,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":1,"ShelfLocCode":"73216","RFID":null,"PaidValue":null,"Medium":"Server","Description":"VLIZ Open Access","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Open access","URL":null,"ClassifID":53,"Classification":"Open access","ReqLink":null,"ClassifTypID":1,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":null,"InternalReq":0,"LoggedInReq":0,"Disclaimer":null,"DutchDisclaimer":null,"FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"Springer-Verlag","City":"New York"}],"MONpubls":null,"pictures":[],"thestermsPath":[{"ThesaurusTerm":"Sponges","ThestID":7913,"Acronym":"ASFA","ThesTermPath":"Animal products > Sponges"},{"ThesaurusTerm":"Bacteria","ThestID":710,"Acronym":"ASFA","ThesTermPath":"Microorganisms > Bacteria"}],"thestermsASFA":[{"ThesaurusTerm":"Bacteria"},{"ThesaurusTerm":"Sponges"}],"taxtermsASFA":null,"geotermsASFA":null,"collections":null,"conf":null,"proj":null,"Physdatasets":null,"spcols":null,"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":71595,"AbstractFlag":-1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":71595,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":null,"thesterms":[{"ThesaurusTerm":"Bacteria","ThestID":710,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"},{"ThesaurusTerm":"Sponges","ThestID":7913,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"}],"taxterms":null,"geoterms":null,"othterms":[{"OtherTerm":"Antiangiogenic","OthtID":13428},{"OtherTerm":"Antimicrobial","OthtID":5139},{"OtherTerm":"Hemolytic cytotoxic\r\n","OthtID":13429},{"OtherTerm":"Primmorphs","OthtID":11737}],"asfacodes":null,"asfa2codes":null,"thestermsFRIS":[{"ThesaurusTerm":"Bacteria","DutchTerm":"Bacteriën","ThestID":710,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"},{"ThesaurusTerm":"Sponges","DutchTerm":null,"ThestID":7913,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"}],"taxtermsFRIS":null,"geotermsFRIS":null,"othtermsFRIS":[{"OtherTerm":"Antiangiogenic","DutchTerm":null,"OthtID":13428},{"OtherTerm":"Antimicrobial","DutchTerm":null,"OthtID":5139},{"OtherTerm":"Hemolytic cytotoxic\r\n","DutchTerm":null,"OthtID":13429},{"OtherTerm":"Primmorphs","DutchTerm":null,"OthtID":11737}],"resmessage":"","complete":1,"sessions":{"newSesName":"Chisala, Chilekwa, C.","newSesDate":{"date":"2005-08-29 10:12:24.407000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Haspeslagh, Jan, J.","updSesDate":{"date":"2005-09-05 09:33:30.240000","timezone_type":3,"timezone":"Europe/Brussels"}}}