{"refrec":{"BRefID":76684,"RR":"<b>Bach, L.; Palmqvist, A.; Rasmussen, L.J.; Forbes, V.E.</b> (2005). Differences in PAH tolerance between <i>Capitella</i> species: underlying biochemical mechanisms. <i>Aquat. Toxicol. 74(4)</i>: 307-319. <a href=\"https://dx.doi.org/10.1016/j.aquatox.2005.06.002\" target=\"_blank\">https://dx.doi.org/10.1016/j.aquatox.2005.06.002</a>","BEntID":72278,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Aquat. Toxicol. 74(4)</i>: 307-319. <a href=\"https://dx.doi.org/10.1016/j.aquatox.2005.06.002\" target=\"_blank\">https://dx.doi.org/10.1016/j.aquatox.2005.06.002</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Bach, L.; Palmqvist, A.; Rasmussen, L.J.; Forbes, V.E.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Bach, L. <i>et al.</i>","Englishabstract":"The polychaete <i>Capitella capitata</i> consists of a species complex within which differences in tolerance to toxicants have been observed. For example, it has been shown that <i>Capitella</i> sp. S is more sensitive (e.g., in terms of survival, growth and reproduction) to PAH and other stressors than the more opportunistic <i>Capitella</i> sp. I, which is able to take up and biotransform the PAH fluoranthene (Flu). In the present study, an investigation was performed to examine whether differences in tolerance between <i>Capitella</i> species sp. I and sp. S are due to differences in biotransformation, measured as the amount of Flu-metabolites produced by worms. We exposed both sibling species to sediment contaminated with 21 and 26 μg Flu/g dry weight sed for 10–15 days. We found that <i>Capitella</i> sp. I took up more Flu from the sediment than sp. S (346 μg Flu eq./g dry weight worm versus 219 μg Flu eq./g dry weight worm, respectively), but as sp. I was much more effective at biotransforming this PAH (62% versus 11%, respectively of total Flu), the net amounts of parent Flu accumulated by the two species were similar. We found significant differences in the subcellular distribution of Flu and its metabolites between sibling species, with sp. I accumulating mostly in the cytosol and sp. S accumulating mostly in the membrane fraction. A previous study by our group showed Flu to be genotoxic to sp. I upon biotransformation. In the present study, we found no detectable genotoxicity in sp. S following Flu exposure. Our results demonstrate that DNA damage is tightly coupled to biotransformation ability and that other aspects of PAH toxicity (e.g., membrane disruption) are more relevant than DNA damage for predicting tolerance differences between these species.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Differences in PAH tolerance between <i>Capitella</i> species: underlying biochemical mechanisms","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2025-07-02 08:33:14.980000","timezone_type":1,"timezone":"+00:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"benthos; biomarker; polycyclic aromatic hydrocarbons; biotransformation;subcellular distribution; comet assay","OtherDescriptors":null,"Notes":null,"AnaPub":2005,"MonPub":null,"DateUpdate":"2019-08-16","DateCreate":"2005-09-22","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000232043200003","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.aquatox.2005.06.002"},"refs":null,"anarec":{"AnaID":76684,"PubliDate":2005,"Pagination":"307-319","XtraPublOfAnaID":null,"ISBN":null,"Volume":"74","Issue":"4","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42203,"SerRR":"Aquatic Toxicology. 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