{"refrec":{"BRefID":77347,"RR":"<b>de Swart, R.L.; Kluten, R.M.G.; Huizing, C.J.; Vedder, L.J.; Reijnders, P.J.H.; Visser, I.K.G.; Uytdehaag, F.G.C.M.; Osterhaus, A.D.M.E.</b> (1993). Mitogen and antigen induced B and T cell responses of peripheral blood mononuclear cells from the harbour seal (<i>Phoca vitulina</i>), <b><i>in</i></b>: de Swart, R.L. (1995). <i>Impaired immunity in seals exposed to bioaccumulated environmental contaminants = Immuunsuppressie in zeehonden blootgesteld aan in de voedselketen geaccumuleerde milieuvervuilende stoffen.</i> pp. 23-34","BEntID":306799,"PublicFlag":1,"CheckedFlag":0,"wosflag":0,"vabbflag":0,"RefStringPartII":", <b><i>in</i></b>: de Swart, R.L. (1995). <i>Impaired immunity in seals exposed to bioaccumulated environmental contaminants = Immuunsuppressie in zeehonden blootgesteld aan in de voedselketen geaccumuleerde milieuvervuilende stoffen.</i> pp. 23-34","DocTypID":17,"DocType":"Book chapters","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"de Swart, R.L.; Kluten, R.M.G.; Huizing, C.J.; Vedder, L.J.; Reijnders, P.J.H.; Visser, I.K.G.; Uytdehaag, F.G.C.M.; Osterhaus, A.D.M.E.","OrigTitleTranslFlag":0,"Authorstringtrunc":"de Swart, R.L. <i>et al.</i>","Englishabstract":"In vitro assays were developed for studies concerning the functioning of the immune system of the harbour seal (<i>Phoca vitulina</i>). Proliferative responses of peripheral blood mononuclear cells (PBMC) were measured after stimulation with different concentrations of the mitogens concanavalin A (Con A), pokeweed mitogen (PWM), phytohaemagglutinin (PHA) or lipopolysaccharide from Salmonella typhimurium (LPS). Con A and PWM induced strong proliferative responses, which PHA and LPS induced comparatively low proliferative responses. Antigen-specific immune responses were measured after immunization of seals with an inactivated rabies vaccine and/or with tetanus toxoid. Antigen-specific proliferation of PBMC and the presence of antigen-specific antibody forming cells were demonstrated for both antigen s in the PBMC of immunized animals. The responses measured in vitro correlated well with the development of specific serum antibody titers to these antigens.","AbstractOtherLang":null,"BibLvlCode":"AM","StandardTitle":"Mitogen and antigen induced B and T cell responses of peripheral blood mononuclear cells from the harbour seal (<i>Phoca vitulina</i>)","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":1993,"MonPub":null,"DateUpdate":"2019-08-27","DateCreate":"2005-10-24","SecASFANote":null,"ConfID":null,"PeerRev":0,"VlizCoreFlag":1,"WoScode":null,"VABBcode":null,"OpenAcc":0},"refs":null,"anarec":{"AnaID":77347,"PubliDate":1993,"Pagination":"23-34","XtraPublOfAnaID":null,"ISBN":"90-9008419-3","Volume":null,"Issue":null,"BRefMon":77338,"BRefMonRR":"<b>de Swart, R.L.</b> (1995). Impaired immunity in seals exposed to bioaccumulated environmental contaminants = Immuunsuppressie in zeehonden blootgesteld aan in de voedselketen geaccumuleerde milieuvervuilende stoffen. PhD Thesis. Erasmus Universiteit Rotterdam: Rotterdam. ISBN 90-9008419-3. 140 pp.","BRefXtra":null,"BRefXtraRR":null,"SerBRefID":null,"SerRR":null,"StandardTitleSer":null,"ISSN":null,"AbbrevSer":null,"StandardTitleMon":"Impaired immunity in seals exposed to bioaccumulated environmental contaminants = Immuunsuppressie in zeehonden blootgesteld aan in de voedselketen geaccumuleerde milieuvervuilende stoffen","StartPage":23,"Pages":12,"ToPubliDate":null,"BRefBibLvlCode":"M","SerNotes":null,"AutString":"de Swart, R.L."},"monrec":null,"serrec":null,"relations":null,"relationsRev":[{"XBRefID":77346,"RefStrFull":"<b>de Swart, R.L.; Kluten, R.M.G.; Huizing, C.J.; Vedder, L.J.; Reijnders, P.J.H.; Visser, I.K.G.; Uytdehaag, F.G.C.M.; Osterhaus, A.D.M.E.</b> (1993). Mitogen and antigen induced B and T cell responses of peripheral blood mononuclear cells from the harbour seal (<i>Phoca vitulina</i>). <i>Vet. Immunol. Immunopathol. 37(3-4)</i>: 217-230. <a href=\"https://dx.doi.org/10.1016/0165-2427(93)90195-A\" target=\"_blank\">https://dx.doi.org/10.1016/0165-2427(93)90195-A</a>","RelID":4,"RelationY":"Related to","StandardTitle":"Mitogen and antigen induced B and T cell responses of peripheral blood mononuclear cells from the harbour seal (<i>Phoca vitulina</i>)"}],"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"de 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