{"refrec":{"BRefID":77410,"RR":"<b>Goksøyr, A.; Larsen, H.E.; Blom, S.; Förlin, L.</b> (1992). Detection of cytochrome P450 1A1 in North Sea dab liver and kidney. <i>Mar. Ecol. Prog. Ser. 91(1-3)</i>: 83-88","BEntID":72992,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Mar. Ecol. Prog. Ser. 91(1-3)</i>: 83-88","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Goksøyr, A.; Larsen, H.E.; Blom, S.; Förlin, L.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Goksøyr, A. <i>et al.</i>","Englishabstract":"Liver and kidney tissue of dab <i>Limanda limanda</i> were analyzed during the Bremerhaven Workshop by immunochemical and catalytic assays for cytochrome P450 1A1 induction. Antibodies to cod P450 1A1 cross-reacted with a protein of M<sub>r</sub> = 58 000 daltons in the dab liver samples, suggested to be the dab P450 1A1 protein. By employing a recently developed indirect ELISA with these antibodies, we observed elevated levels of P450 1A1 protein in the innermost stations of the German Bight transect in both liver and kidney (head and trunk kidney) samples. Ethoxyresorufin O-deethylase (EROD) activities in trunk kidney were also elevated in the innermost stations. Along the drilling station gradient no induction could be detected. Immuno-detection of the cytochrome P450 1A1 induction response should provide a convenient indicator for biological effects of several classes of organic contaminants.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Detection of cytochrome P450 1A1 in North Sea dab liver and kidney","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2025-07-02 08:33:14.980000","timezone_type":1,"timezone":"+00:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":1992,"MonPub":null,"DateUpdate":"2021-02-24","DateCreate":"2005-10-26","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:A1992LL06400011","VABBcode":null,"OpenAcc":1},"refs":null,"anarec":{"AnaID":77410,"PubliDate":1992,"Pagination":"83-88","XtraPublOfAnaID":null,"ISBN":null,"Volume":"91","Issue":"1-3","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":43354,"SerRR":"Marine Ecology Progress Series. Inter-Research: Oldendorf/Luhe.  ISSN 0171-8630; e-ISSN 1616-1599","StandardTitleSer":"Marine Ecology Progress Series","ISSN":"0171-8630","AbbrevSer":"Mar. Ecol. Prog. Ser.","StandardTitleMon":null,"StartPage":83,"Pages":6,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":[{"YBRefID":77389,"RefStrFull":"<b>Stebbing, A.R.D.; Dethlefsen, V.; Carr, M. (Ed.)</b> (1992). Biological effects of contaminants in the North Sea: Results of the ICES/IOC Bremerhaven Workshop. <i>Marine Ecology Progress Series</i>, 91(1-3). Inter-Research: Amelinghausen. 361 pp.","RelID":10,"Relation":"Also appears in","StandardTitle":"Biological effects of contaminants in the North Sea: Results of the ICES/IOC Bremerhaven Workshop"}],"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Goksøyr","Firstname":null,"Initials":"A.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":72992,"AutID":7042,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Larsen","Firstname":null,"Initials":"H.E.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":72992,"AutID":55984,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Blom","Firstname":"Sonja","Initials":"S.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":72992,"AutID":55985,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Förlin","Firstname":null,"Initials":"L.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":72992,"AutID":7014,"OrderNr":4,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":358570,"LibID":36,"BRefID":77410,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":1,"ShelfLocCode":"358570","RFID":null,"PaidValue":null,"Medium":"Server","Description":"VLIZ Open Access","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Open access","URL":null,"ClassifID":53,"Classification":"Open access","ReqLink":null,"ClassifTypID":1,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":null,"InternalReq":0,"LoggedInReq":0,"Disclaimer":null,"DutchDisclaimer":null,"FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"Inter-Research","City":"Oldendorf/Luhe"}],"MONpubls":null,"pictures":[],"thestermsPath":[{"ThesaurusTerm":"Kidneys","ThestID":4549,"Acronym":"ASFA","ThesTermPath":"Anatomical structures > Body organs > Animal organs > Excretory organs > Kidneys"},{"ThesaurusTerm":"ANE, North Sea","ThestID":182108,"Acronym":"ASFA_GEOT","ThesTermPath":"ANE, North Sea"},{"ThesaurusTerm":"Cytochromes","ThestID":2070,"Acronym":"ASFA","ThesTermPath":"Enzymes > Coenzymes > Cytochromes"},{"ThesaurusTerm":"Pollution indicators","ThestID":6393,"Acronym":"ASFA","ThesTermPath":"Indicators > Pollution indicators"},{"ThesaurusTerm":"Liver","ThestID":4794,"Acronym":"ASFA","ThesTermPath":"Secretory organs > Glands > Exocrine glands > Digestive system > Digestive glands > Liver"}],"thestermsASFA":[{"ThesaurusTerm":"ANE, North Sea"},{"ThesaurusTerm":"Cytochromes"},{"ThesaurusTerm":"Kidneys"},{"ThesaurusTerm":"Liver"},{"ThesaurusTerm":"Pollution indicators"}],"taxtermsASFA":[{"TaxTerm":"Limanda limanda (Linnaeus, 1758)"}],"geotermsASFA":[{"GeoTerm":"North Sea"}],"collections":null,"conf":null,"proj":null,"Physdatasets":null,"spcols":null,"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":72992,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":72992,"AbstractFlag":1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":null,"thesterms":[{"ThesaurusTerm":"ANE, North Sea","ThestID":182108,"Acronym":"ASFA_GEOT","ThesTypID":34,"ThesType":"ASFA Geoterms"},{"ThesaurusTerm":"Cytochromes","ThestID":2070,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"},{"ThesaurusTerm":"Kidneys","ThestID":4549,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"},{"ThesaurusTerm":"Liver","ThestID":4794,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"},{"ThesaurusTerm":"Pollution indicators","ThestID":6393,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"}],"taxterms":[{"TaxTerm":"Limanda limanda (Linnaeus, 1758) [Dab]","AphiaID":127139,"TaxtID":16286}],"geoterms":[{"GeoTerm":"North Sea","GeoObjectID":2350,"GeotID":390}],"othterms":null,"asfacodes":null,"asfa2codes":null,"thestermsFRIS":[{"ThesaurusTerm":"ANE, North Sea","DutchTerm":null,"ThestID":182108,"Acronym":"ASFA_GEOT","ThesTypID":34,"ThesType":"ASFA Geoterms"},{"ThesaurusTerm":"Cytochromes","DutchTerm":null,"ThestID":2070,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"},{"ThesaurusTerm":"Kidneys","DutchTerm":null,"ThestID":4549,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"},{"ThesaurusTerm":"Liver","DutchTerm":"Lever","ThestID":4794,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"},{"ThesaurusTerm":"Pollution indicators","DutchTerm":"Pollutieindicators","ThestID":6393,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"}],"taxtermsFRIS":[{"TaxTerm":"Limanda limanda (Linnaeus, 1758)","DutchTerm":"Schar","AphiaID":127139,"TaxtID":16286}],"geotermsFRIS":[{"GeoTerm":"North Sea","DutchTerm":"Noordzee"}],"othtermsFRIS":null,"resmessage":"","complete":1,"sessions":{"newSesName":"Chisala, Chilekwa, C.","newSesDate":{"date":"2005-10-26 09:17:47.093000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Bouchti, Zohra, Z.","updSesDate":{"date":"2021-02-24 06:31:12.250000","timezone_type":3,"timezone":"Europe/Brussels"}}}
