{"refrec":{"BRefID":78797,"RR":"<b>Hassenklöver, T.; Predehl, S.; Pilli, J.; Ledwolorz, J.; Assmann, M.; Bickmeyer, U.</b> (2006). Bromophenols, both present in marine organisms and in industrial flame retardants, disturb cellular Ca<sup>2+</sup> signaling in neuroendocrine cells (PC12). <i>Aquat. Toxicol. 76(1)</i>: 37-45. <a href=\"https://dx.doi.org/10.1016/j.aquatox.2005.09.004\" target=\"_blank\">https://dx.doi.org/10.1016/j.aquatox.2005.09.004</a>","BEntID":74326,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Aquat. Toxicol. 76(1)</i>: 37-45. <a href=\"https://dx.doi.org/10.1016/j.aquatox.2005.09.004\" target=\"_blank\">https://dx.doi.org/10.1016/j.aquatox.2005.09.004</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Hassenklöver, T.; Predehl, S.; Pilli, J.; Ledwolorz, J.; Assmann, M.; Bickmeyer, U.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Hassenklöver, T. <i>et al.</i>","Englishabstract":"Bromophenols are present in polychaetes as well as in algae in marine environments including the North Sea. They are thought to cause the typical sea-like taste and flavour. The ecological function of brominated phenols is not clear yet, but they may play a role in chemical defence and deterrence [Kicklighter, C.E., Kubaneck, J., Hay, M.E., 2004. Do brominated natural products defend marine worms from consumers? Some do, most don’t. Limnol. Oceanogr. 49, 430–441]. Some brominated phenols are commercially used as industrial flame retardants as, e.g., 2,4,6-tribromophenol and are suspected to disrupt the humoral system by showing tyroid hormone-like activity [Legler, I., Brouwer, A., 2003. Are brominated flame retardants endocrine disruptors? Environ. Int. 29, 879–885]. In this study 2-bromophenol (2-BP), 4-bromophenol (4-BP), 2,4-dibromophenol (2,4-DBP), 2,6-dibromophenol (2,6-DBP) and 2,4,6-tribromophenol (2,4,6-TBP), all of which are present in marine organisms, were tested. Especially 2,4-DBP and 2,4,6-TBP showed a significant effect on the Ca<sup>2+</sup> homeostasis in endocrine cells (PC 12). The reduction of depolarization induced Ca<sup>2+</sup> elevations by 2,4-DBP and 2,4,6-TBP and the increase of intracellular Ca<sup>2+</sup> by both substances, partly released from intracellular stores, may suggest a link to the disrupting effect of endocrine systems by brominated phenols. 2,4-DBP was the most potent substance we tested in respect to inhibition of voltage dependent Ca<sup>2+</sup> currents as revealed in whole cell patch clamp experiments. Brominated phenols disturb cellular Ca<sup>2+</sup> signaling with differential efficacy, depending on the number and position of bromine.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Bromophenols, both present in marine organisms and in industrial flame retardants, disturb cellular Ca<sup>2+</sup> signaling in neuroendocrine cells (PC12)","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-11 01:31:32.878224","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"calcium signaling; neurotoxicology; flame retardant; algae;2,4-dibromophenol; 2,4,6-tribromophenol","OtherDescriptors":null,"Notes":null,"AnaPub":2006,"MonPub":null,"DateUpdate":"2020-10-16","DateCreate":"2006-01-17","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000234621100004","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.aquatox.2005.09.004"},"refs":null,"anarec":{"AnaID":78797,"PubliDate":2006,"Pagination":"37-45","XtraPublOfAnaID":null,"ISBN":null,"Volume":"76","Issue":"1","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42203,"SerRR":"Aquatic Toxicology. Elsevier Science: Tokyo; New York; London; Amsterdam.  ISSN 0166-445X; e-ISSN 1879-1514","StandardTitleSer":"Aquatic Toxicology","ISSN":"0166-445X","AbbrevSer":"Aquat. Toxicol.","StandardTitleMon":null,"StartPage":37,"Pages":9,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":{"Line1":"Im Flor 11","Email":"ubickmeyer@awi.de","Line2":null,"EnvName":"Germany"},"othpubs":null,"ownerships":null,"authors":[{"AutName":"Hassenklöver","Firstname":"Thomas","Initials":"T.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":74326,"AutID":57000,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Predehl","Firstname":"Sabine","Initials":"S.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":74326,"AutID":57001,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Pilli","Firstname":"Jyotsna","Initials":"J.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":74326,"AutID":57002,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Ledwolorz","Firstname":"Jessica","Initials":"J.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":74326,"AutID":57003,"OrderNr":4,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Assmann","Firstname":"Michael","Initials":"M.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":74326,"AutID":57004,"OrderNr":5,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Bickmeyer","Firstname":"Ulf","Initials":"U.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":74326,"AutID":57005,"OrderNr":6,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":352714,"LibID":36,"BRefID":78797,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":null,"ShelfLocCode":"352714","RFID":null,"PaidValue":null,"Medium":"Server","Description":"Interne VLIZ documenten","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Non-open access","URL":null,"ClassifID":228,"Classification":"Non-open access","ReqLink":1,"ClassifTypID":3,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":1,"InternalReq":1,"LoggedInReq":1,"Disclaimer":"Disclaimer_VLIZ_Intern","DutchDisclaimer":"<p>Deze publicatie is enkel beschikbaar voor persoonlijk gebruik binnen de Innovocean site <br />en mag op geen enkele manier verder worden verspreid.</p>","FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"Elsevier Science","City":"Tokyo; New York; London; Amsterdam"}],"MONpubls":null,"pictures":[],"thestermsPath":[{"ThesaurusTerm":"Algae","ThestID":261,"Acronym":"ASFA","ThesTermPath":"Algae"},{"ThesaurusTerm":"Neurotoxins","ThestID":5534,"Acronym":"ASFA","ThesTermPath":"Materials > Hazardous materials > Biological poisons > Neurotoxins"}],"thestermsASFA":[{"ThesaurusTerm":"Algae"},{"ThesaurusTerm":"Neurotoxins"}],"taxtermsASFA":null,"geotermsASFA":null,"collections":null,"conf":null,"proj":null,"Physdatasets":null,"spcols":null,"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":74326,"AbstractFlag":-1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":74326,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":[{"URL":"https://dx.doi.org/10.1016/j.aquatox.2005.09.004","externalID":"10.1016/j.aquatox.2005.09.004","URLTypeCode":"DOI","URLID":4744,"URLTypID":13,"URLType":"DOI","URLPrefix":"http://dx.doi.org/"}],"thesterms":[{"ThesaurusTerm":"Algae","ThestID":261,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"},{"ThesaurusTerm":"Neurotoxins","ThestID":5534,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"}],"taxterms":null,"geoterms":null,"othterms":[{"OtherTerm":"2,4,6-Tribromophenol","OthtID":14056},{"OtherTerm":"2,4-Dibromophenol","OthtID":14055},{"OtherTerm":"Calcium signaling","OthtID":14053},{"OtherTerm":"Flame retardant","OthtID":14054},{"OtherTerm":"Neurotoxicology","OthtID":12435}],"asfacodes":null,"asfa2codes":null,"thestermsFRIS":[{"ThesaurusTerm":"Algae","DutchTerm":"Algen","ThestID":261,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"},{"ThesaurusTerm":"Neurotoxins","DutchTerm":null,"ThestID":5534,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"}],"taxtermsFRIS":null,"geotermsFRIS":null,"othtermsFRIS":[{"OtherTerm":"2,4,6-Tribromophenol","DutchTerm":null,"OthtID":14056},{"OtherTerm":"2,4-Dibromophenol","DutchTerm":null,"OthtID":14055},{"OtherTerm":"Calcium signaling","DutchTerm":null,"OthtID":14053},{"OtherTerm":"Flame retardant","DutchTerm":null,"OthtID":14054},{"OtherTerm":"Neurotoxicology","DutchTerm":null,"OthtID":12435}],"resmessage":"","complete":1,"sessions":{"newSesName":"Chisala, Chilekwa, C.","newSesDate":{"date":"2006-01-17 09:09:32.700000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Bouchti, Zohra, Z.","updSesDate":{"date":"2020-10-16 07:08:25.837000","timezone_type":3,"timezone":"Europe/Brussels"}}}