{"refrec":{"BRefID":8438,"RR":"<b>Abbott, N.J.; Brown, E.R.; Pichon, Y.; Kukita, F.</b> (1995). Electrophysiology of squid Schwann cells, <b><i>in</i></b>: Abbott, N.J. <i>et al.</i> (Ed.) <i>Cephalopod neurobiology: neuroscience studies in squid, octopus and cuttlefish.</i> pp. 197-212","BEntID":8438,"PublicFlag":1,"CheckedFlag":0,"wosflag":null,"vabbflag":null,"RefStringPartII":", <b><i>in</i></b>: Abbott, N.J. <i>et al.</i> <i>Cephalopod neurobiology: neuroscience studies in squid, octopus and cuttlefish.</i> pp. 197-212","DocTypID":17,"DocType":"Book chapters","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Abbott, N.J.; Brown, E.R.; Pichon, Y.; Kukita, F.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Abbott, N.J. <i>et al.</i>","Englishabstract":"Schwann cells of the squid giant nerve fibre form a monolayered sheath around the axon. The accessibility and size of the cells permits microelectrode impalement. The membrane potential is around -40 mV at rest, the result of a membrane predominantly permeable to K<sup>+</sup>. The Schwann cell has a lower internal [K<sup>+</sup>] and higher [Na<sup>+</sup>] than the giant axon, which helps explain the low membrane potential. Resting Cl<sup>­</sup> permeability has not been accurately measured, but may be significant; Cl<sup>-</sup> distribution across the membrane appears to be close to equilibrium. The input impedance of squid Schwann cells is between 3 and 13MΩ. Calculations of membrane resistance depend on assumptions about the effective surface area of the membrane, but figures of 1.2-4.8 kΩ.cm² have been derived, compared with about 1 kΩ.cm² for the axon membrane. Schwann cells are weakly dye- and electrically-coupled in small groups, but the nature of the junctions responsible is unclear. Current injection provides evidence of non-ohmic membrane behaviour, and 'spike-like' transients of potential to depolarizing current steps. Axonal stimulation or addition of glutamate or carbachol causes a long-lasting hyperpolarization of the Schwann cell, associated with increased K<sup>+</sup>-selectivity of the membrane. Transient hyperpolarizations are often seen during this activation, and appear to be due to opening of calcium-activated K<sup>+</sup> channels. The membrane properties may underlie important activities of the Schwann cell including periaxonal ion homeostasis and axon-Schwann cell signalling. The similarities in membrane properties with vertebrate Schwann cells suggest that axon-associated peripheral glial cells may function on similar general principles in vertebrates and invertebrates.","AbstractOtherLang":null,"BibLvlCode":"AM","StandardTitle":"Electrophysiology of squid Schwann cells","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":1995,"MonPub":null,"DateUpdate":"2001-05-08","DateCreate":"2001-05-08","SecASFANote":null,"ConfID":null,"PeerRev":null,"VlizCoreFlag":1,"WoScode":null,"VABBcode":null,"OpenAcc":0},"refs":null,"anarec":{"AnaID":8438,"PubliDate":1995,"Pagination":"197-212","XtraPublOfAnaID":null,"ISBN":"0-19-854790-0","Volume":null,"Issue":null,"BRefMon":8320,"BRefMonRR":"<b>Abbott, N.J.; Williamson, R.; Maddock, L. (Ed.)</b> (1995). Cephalopod neurobiology: Neuroscience studies in squid, octopus and cuttlefish. Oxford University Press: London. ISBN 0-19-854790-0. 542 pp. <a href=\"https://dx.doi.org/10.1093/acprof:oso/9780198547907.001.0001\" target=\"_blank\">https://dx.doi.org/10.1093/acprof:oso/9780198547907.001.0001</a>","BRefXtra":null,"BRefXtraRR":null,"SerBRefID":null,"SerRR":null,"StandardTitleSer":null,"ISSN":null,"AbbrevSer":null,"StandardTitleMon":"Cephalopod neurobiology: Neuroscience studies in squid, octopus and cuttlefish","StartPage":197,"Pages":16,"ToPubliDate":null,"BRefBibLvlCode":"M","SerNotes":null,"AutString":"Abbott, N.J.; Williamson, R.; Maddock, L. (Ed.)"},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Abbott","Firstname":"N. 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