{"refrec":{"BRefID":97616,"RR":"<b>Ghekiere, A.; Verslycke, T.; Fockedey, N.; Janssen, C.R.<\/b> (2006). Non-target effects of the insecticide methoprene on molting in the estuarine crustacean <i>Neomysis integer<\/i> (Crustacea: Mysidacea). <i>J. Exp. Mar. Biol. Ecol. 332(2)<\/i>: 226-234. <a href=\"http:\/\/dx.doi.org\/10.1016\/j.jembe.2005.11.021\" target=\"_blank\">dx.doi.org\/10.1016\/j.jembe.2005.11.021<\/a>","BEntID":93040,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":null,"RefStringPartII":". <i>J. Exp. Mar. Biol. Ecol. 332(2)<\/i>: 226-234. <a href=\"https:\/\/dx.doi.org\/10.1016\/j.jembe.2005.11.021\" target=\"_blank\">https:\/\/dx.doi.org\/10.1016\/j.jembe.2005.11.021<\/a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":1,"TerrestrialFlag":0,"Authorstring":"Ghekiere, A.; Verslycke, T.; Fockedey, N.; Janssen, C.R.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Ghekiere, A. <i>et al.<\/i>","Englishabstract":"Ecdysteroids, the molting hormones in crustaceans and other arthropods, play a crucial role in the control of growth, reproduction and embryogenesis of these organisms. Insecticides are often designed to target specific endocrine-regulated functions such as molting and larval development such as methoprene, a juvenile hormone analogue.The aim of this study was to examine the effects of methoprene on molting in a non-target species, the estuarine mysid <i>Neomysis integer<\/i> (Crustacea: Mysidacea). Mysids have been proposed as standard test organisms for evaluating the endocrine disruptive effect of chemicals. Juveniles (< 24 h) were exposed for 3 weeks to the nominal concentrations 0.01, 1 and 100 \u00b5g methoprene\/l. Daily, present molts were checked and stored in 4% formaldehyde for subsequent growth measurements. Methoprene significantly delayed molting at 100 \u00b5g\/l by decreasing the growth rate and increasing the intermolt period. This resulted in a decreased wet weight of the organism. The anti-ecdysteroidal properties of methoprene on mysid molting were also evaluated by determining the ability of exogenously administered 20-hydroxyecdysone, the active ecdysteroid in crustaceans, to protect against the observed methoprene effects. Co-exposure to 20-hydroxyecdysone did not mitigate methoprene effects on mysid molting. This study demonstrates the need for incorporating invertebrate-specific hormone-regulated endpoints in regulatory screening and testing programs for the detection of endocrine disruption caused by man-made chemicals.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Non-target effects of the insecticide methoprene on molting in the estuarine crustacean <i>Neomysis integer<\/i> (Crustacea: Mysidacea)","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"endocrine disruption; juvenile hormone analog; molting; methoprene; Neomysis integer","OtherDescriptors":null,"Notes":null,"AnaPub":2006,"MonPub":null,"DateUpdate":"2012-11-23","DateCreate":"2006-04-05","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000237767100010","VABBcode":null,"OpenAcc":0,"DOI":"10.1016\/j.jembe.2005.11.021"},"refs":null,"anarec":{"AnaID":97616,"PubliDate":2006,"Pagination":"226-234","XtraPublOfAnaID":null,"ISBN":null,"Volume":"332","Issue":"2","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":43229,"SerRR":"Journal of Experimental Marine Biology and Ecology. 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