{"refrec":{"BRefID":304937,"RR":"<b>Asselman, J.; Van Acker, E.; De Rijcke, M.; Tilleman, L.; Van Nieuwerburgh, F.; Mees, J.; De Schamphelaere, K.; Janssen, C.</b> (2019). Marine biogenics in sea spray aerosols interact with the mTOR signaling pathway. <i>NPG Scientific Reports 9(1)</i>: 675. <a href=\"https://dx.doi.org/10.1038/s41598-018-36866-3\" target=\"_blank\">https://dx.doi.org/10.1038/s41598-018-36866-3</a>","BEntID":297232,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>NPG Scientific Reports 9(1)</i>: 675. <a href=\"https://dx.doi.org/10.1038/s41598-018-36866-3\" target=\"_blank\">https://dx.doi.org/10.1038/s41598-018-36866-3</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Asselman, J.; Van Acker, E.; De Rijcke, M.; Tilleman, L.; Van Nieuwerburgh, F.; Mees, J.; De Schamphelaere, K.; Janssen, C.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Asselman, J. <i>et al.</i>","Englishabstract":"Sea spray aerosols (SSAs) have profound effects on our climate and ecosystems. They also contain microbiota and biogenic molecules which could affect human health. Yet the exposure and effects of SSAs on human health remain poorly studied. Here, we exposed human lung cancer cells to extracts of a natural sea spray aerosol collected at the seashore in Belgium, a laboratory-generated SSA, the marine algal toxin homoyessotoxin and a chemical inhibitor of the mammalian target of rapamycin (mTOR) pathway. We observed significant increased expression of genes related to the mTOR pathway and Proprotein convertase subtilisin/kexin type 9 (PCSK9) after exposure to homoyessotoxin and the laboratory-generated SSA. In contrast, we observed a significant decrease in gene expression in the mTOR pathway and of PCSK9 after exposure to the natural SSA and the mTOR inhibitor, suggesting induction of apoptosis. Our results indicate that marine biogenics in SSAs interact with PCSK9 and the mTOR pathway and can be used in new potential pharmaceutical applications. Overall, our results provide a substantial molecular evidence base for potential beneficial health effects at environmentally relevant concentrations of natural SSAs.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Marine biogenics in sea spray aerosols interact with the mTOR signaling pathway","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-20 01:32:30.436452","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2019,"MonPub":null,"DateUpdate":"2022-05-25","DateCreate":"2019-01-24","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000456554600114","VABBcode":"vabb:480352","OpenAcc":1,"DOI":"10.1038/s41598-018-36866-3"},"refs":null,"anarec":{"AnaID":304937,"PubliDate":2019,"Pagination":"675","XtraPublOfAnaID":null,"ISBN":null,"Volume":"9","Issue":"1","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":208093,"SerRR":"Scientific Reports (Nature Publishing Group). Nature Publishing Group: London.  ISSN 2045-2322; e-ISSN 2045-2322","StandardTitleSer":"Scientific Reports (Nature Publishing Group)","ISSN":"2045-2322","AbbrevSer":"NPG Scientific Reports","StandardTitleMon":null,"StartPage":675,"Pages":null,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Asselman","Firstname":"Jana","Initials":"J.","Affiliation":"Laboratory of Environmental Toxicology and Aquatic Ecology, Environmental Toxicology Unit - GhEnToxLab, Ghent University","Discriminator":null,"CorporateFlag":0,"BEntID":297232,"AutID":207311,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":"GhEnToxLab","InsFSN":"Universiteit Gent; Faculteit Bio-ingenieurswetenschappen; Vakgroep Dierwetenschappen en Aquatische Ecologie; Laboratorium voor Milieutoxicologie","ORCID":"0000-0003-0185-6516","PersID":31905,"InsID":6705},{"AutName":"Van Acker","Firstname":"Emmanuel","Initials":"E.","Affiliation":"Laboratory of Environmental Toxicology and Aquatic Ecology: Environmental Toxicology Unit – GhEnToxLab, Ghent University","Discriminator":null,"CorporateFlag":0,"BEntID":297232,"AutID":207728,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":"GhEnToxLab","InsFSN":"Universiteit Gent; Faculteit Bio-ingenieurswetenschappen; Vakgroep Dierwetenschappen en Aquatische Ecologie; Laboratorium voor Milieutoxicologie","ORCID":null,"PersID":31904,"InsID":6705},{"AutName":"De Rijcke","Firstname":"Maarten","Initials":"M.","Affiliation":"Flanders Marine Institute (VLIZ","Discriminator":null,"CorporateFlag":0,"BEntID":297232,"AutID":320338,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":"VLIZ","InsFSN":"Vlaams Instituut voor de Zee","ORCID":"0000-0002-0899-8122","PersID":25439,"InsID":36},{"AutName":"Tilleman","Firstname":"Laurentijn","Initials":"L.","Affiliation":"Laboratory for Pharmaceutical Biotechnology, Faculty of Pharmaceutical Sciences, Ghent University","Discriminator":null,"CorporateFlag":0,"BEntID":297232,"AutID":337843,"OrderNr":4,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Van Nieuwerburgh","Firstname":"Filip","Initials":"F.","Affiliation":"Laboratory of Pharmaceutical Biotechnology, Faculty of Pharmaceutical Sciences, Ghent University","Discriminator":null,"CorporateFlag":0,"BEntID":297232,"AutID":197430,"OrderNr":5,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Mees","Firstname":"Jan","Initials":"J.","Affiliation":"Flanders Marine Institute (VLIZ)","Discriminator":null,"CorporateFlag":0,"BEntID":297232,"AutID":144839,"OrderNr":6,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":"VLIZ","InsFSN":"Vlaams Instituut voor de Zee","ORCID":"0000-0001-5709-3816","PersID":48,"InsID":36},{"AutName":"De Schamphelaere","Firstname":"Karel","Initials":"K.","Affiliation":"Laboratory of Environmental Toxicology and Aquatic Ecology, Environmental Toxicology Unit (GhEnToxLab), Ghent University","Discriminator":null,"CorporateFlag":0,"BEntID":297232,"AutID":207403,"OrderNr":7,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":"GhEnToxLab","InsFSN":"Universiteit Gent; Faculteit Bio-ingenieurswetenschappen; Vakgroep Dierwetenschappen en Aquatische Ecologie; Laboratorium voor Milieutoxicologie","ORCID":"0000-0002-5063-922X","PersID":2823,"InsID":6705},{"AutName":"Janssen","Firstname":"Colin","Initials":"C.","Affiliation":"Laboratory of Environmental Toxicology and Aquatic Ecology; Environmental Toxicology Unit – GhEnToxLab, Ghent University","Discriminator":null,"CorporateFlag":0,"BEntID":297232,"AutID":207361,"OrderNr":8,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":"GhEnToxLab","InsFSN":"Universiteit Gent; Faculteit Bio-ingenieurswetenschappen; Vakgroep Dierwetenschappen en Aquatische Ecologie; Laboratorium voor Milieutoxicologie","ORCID":"0000-0002-7781-6679","PersID":50,"InsID":6705}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":322839,"LibID":36,"BRefID":304937,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":1,"ShelfLocCode":"322839","RFID":null,"PaidValue":null,"Medium":"Server","Description":"VLIZ Open Access","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Open access","URL":null,"ClassifID":53,"Classification":"Open access","ReqLink":null,"ClassifTypID":1,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":null,"InternalReq":0,"LoggedInReq":0,"Disclaimer":null,"DutchDisclaimer":null,"FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"Nature Publishing Group","City":"London"}],"MONpubls":null,"pictures":[],"thestermsPath":null,"thestermsASFA":null,"taxtermsASFA":null,"geotermsASFA":null,"collections":[{"Collection":"OMA - Open Marien Archief","ShortName":"OMA"},{"Collection":"VLIZ Acknowledged Publications","ShortName":"VLIZ ackn"}],"conf":null,"proj":null,"Physdatasets":null,"spcols":{"222":{"SpName":"BMB - Belgische Mariene Bibliografie","SpColID":222,"ParSpColID":null,"TopParID":null,"ShortName":"BMB","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":null,"SpColPath":"BMB"},"992":{"SpName":"FRIS (VLIZ) - Flanders Research Information Space","SpColID":992,"ParSpColID":null,"TopParID":null,"ShortName":"FRIS","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":null,"SpColPath":"FRIS"},"221":{"SpName":"OMA - Open Marien Archief","SpColID":221,"ParSpColID":null,"TopParID":null,"ShortName":"OMA","URLLocation":null,"LibID":36,"OpenRepoFlag":1,"SpTypID":null,"TopParIDNotWebsite":null,"SpColPath":"OMA"},"1064":{"SpName":"Peer reviewed VLIZ publications","SpColID":1064,"ParSpColID":null,"TopParID":null,"ShortName":"PR VLIZ pubs","URLLocation":null,"LibID":null,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":null,"SpColPath":"PR VLIZ pubs"},"39":{"SpName":"VLIZ Acknowledged Publications","SpColID":39,"ParSpColID":null,"TopParID":null,"ShortName":"VLIZ ackn","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":null,"SpColPath":"VLIZ ackn"},"746":{"SpName":"VLIZ website","SpColID":746,"ParSpColID":null,"TopParID":null,"ShortName":null,"URLLocation":null,"LibID":null,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":null,"SpColPath":"VLIZ website"},"751":{"SpName":"VLIZ website: Pollution and human health: Human health","SpColID":751,"ParSpColID":746,"TopParID":746,"ShortName":" Human health","URLLocation":null,"LibID":null,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":746,"SpColPath":"VLIZ website/ Human health"}},"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":297232,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":297232,"AbstractFlag":1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":[{"URL":"https://dx.doi.org/10.1038/s41598-018-36866-3","externalID":"10.1038/s41598-018-36866-3","URLTypeCode":"DOI","URLID":70057,"URLTypID":13,"URLType":"DOI","URLPrefix":"http://dx.doi.org/"}],"thesterms":null,"taxterms":null,"geoterms":null,"othterms":null,"asfacodes":null,"asfa2codes":null,"thestermsFRIS":null,"taxtermsFRIS":null,"geotermsFRIS":null,"othtermsFRIS":null,"resmessage":"","complete":1,"sessions":{"newSesName":"Chisala, Chilekwa, C.","newSesDate":{"date":"2019-01-24 11:41:42.297000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Bouchti, Zohra, Z.","updSesDate":{"date":"2022-05-25 09:11:06.720000","timezone_type":3,"timezone":"Europe/Brussels"}}}