{"refrec":{"BRefID":337366,"RR":"<b>Bonneure, E.; De Baets, A.; De Decker, S.; Van den Berge, K.; Clement, L.; Vyverman, W.; Mangelinckx, S.</b> (2021). Altering the sex pheromone cyclo(L-Pro-L-Pro) of the diatom <i>Seminavis robusta</i> towards a chemical probe. <i>International Journal of Molecular Sciences 22(3)</i>: 1037. <a href=\"https://hdl.handle.net/10.3390/ijms22031037\" target=\"_blank\">https://hdl.handle.net/10.3390/ijms22031037</a>","BEntID":333988,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>International Journal of Molecular Sciences 22(3)</i>: 1037. <a href=\"https://hdl.handle.net/10.3390/ijms22031037\" target=\"_blank\">https://hdl.handle.net/10.3390/ijms22031037</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Bonneure, E.; De Baets, A.; De Decker, S.; Van den Berge, K.; Clement, L.; Vyverman, W.; Mangelinckx, S.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Bonneure, E. <i>et al.</i>","Englishabstract":"As a major group of algae, diatoms are responsible for a substantial part of the primary production on the planet. Pennate diatoms have a predominantly benthic lifestyle and are the most species-rich diatom group, with members of the raphid clades being motile and generally having heterothallic sexual reproduction. It was recently shown that the model species <i>Seminavis robusta</i> uses multiple sexual cues during mating, including cyclo(L-Pro-L-Pro) as an attraction pheromone. Elaboration of the pheromone-detection system is a key aspect in elucidating pennate diatom life-cycle regulation that could yield novel fundamental insights into diatom speciation. This study reports the synthesis and bio-evaluation of seven novel pheromone analogs containing small structural alterations to the cyclo(L-Pro-L-Pro) pheromone. Toxicity, attraction, and interference assays were applied to assess their potential activity as a pheromone. Most of our analogs show a moderate-to-good bioactivity and low-to-no phytotoxicity. The pheromone activity of azide- and diazirine-containing analogs was unaffected and induced a similar mating behavior as the natural pheromone. These results demonstrate that the introduction of confined structural modifications can be used to develop a chemical probe based on the diazirine- and/or azide-containing analogs to study the pheromone-detection system of <i>S. robusta</i>.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Altering the sex pheromone cyclo(L-Pro-L-Pro) of the diatom <i>Seminavis robusta</i> towards a chemical probe","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:01.897972","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"diatom; pheromone; diketopiperazine; chemical probe; diazirine","OtherDescriptors":null,"Notes":null,"AnaPub":2021,"MonPub":null,"DateUpdate":"2021-10-05","DateCreate":"2021-05-17","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000615291500001","VABBcode":null,"OpenAcc":1,"Handle":"10.3390/ijms22031037"},"refs":null,"anarec":{"AnaID":337366,"PubliDate":2021,"Pagination":"1037","XtraPublOfAnaID":null,"ISBN":null,"Volume":"22","Issue":"3","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":270393,"SerRR":"International Journal of Molecular Sciences. 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