Venom peptides as therapeutics: advances, challenges and the future of venom-peptide discovery
Robinson, S.D.; Undheim, E.A.B.; Ueberheide, B.; King, G.F. (2017). Venom peptides as therapeutics: advances, challenges and the future of venom-peptide discovery. Expert Review of Proteomics 14(10): 931-939. https://dx.doi.org/10.1080/14789450.2017.1377613
In: Expert Review of Proteomics. TAYLOR & FRANCIS LTD: Abingdon. ISSN 1478-9450; e-ISSN 1744-8387, more
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| Author keywords |
Venom, peptide, toxin, mass spectrometry, proteome, transcriptome |
| Authors | | Top |
- Robinson, S.D.
- Undheim, E.A.B.
- Ueberheide, B.
- King, G.F.
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| Abstract |
Introduction: Animal venoms are complex chemical arsenals. Most venoms are rich in bioactive peptides with proven potential as research tools, drug leads and drugs.Areas covered: We review recent advances in venom-peptide discovery, particularly the adoption of combined transcriptomic/proteomic approaches for the exploration of venom composition.Expert commentary: Advances in transcriptomics and proteomics have dramatically altered the manner and rate of venom-peptide discovery. The increasing trend towards a toxin-driven approach, as opposed to traditional target-based screening of venoms, is likely to expedite the discovery of venom-peptides with novel structures and new and unanticipated mechanisms of action. At the same time, these advances will drive the development of higher-throughput approaches for target identification. Taken together, these approaches should enhance our understanding of the natural ecological function of venom peptides and increase the rate of identification of novel venom-derived pharmacological tools, drug leads and drugs. |
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