| Keywords |
Climate change
Natural products
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| Author keywords |
Chemistry; Isolation and purification; Drugs from the sea; Genome-based drug discovery; Anticancer agents; Antiinfective agents; Antipain therapeutics; Chemical ecology; Ethical drug discovery |
| Authors | | Top |
- Antunes, E.M.
- Beukes, D.R.
- Caro-Diaz, E.J.E.
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- Narchi, N.E.
- Tan, L.K.
- Gerwick, W.H.
|
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| Abstract |
This chapter describes the human medicines that have been derived from or inspired by the natural products of marine organisms. We review some little-known aspects of the history of this field of drug discovery from the sea, review the methods and approaches that have been used, and then provide some in-depth discussion of the approved clinically useful drugs from the sea. We also describe those agents that are in clinical trials for a medical indication, as well as a few preclinical lead compounds. We complete our chapter with a description of how chemical ecology studies can enhance drug discovery efforts, the perceived impacts of climate change on this field, ethical issues of marine drug discovery from foreign countries, and some forward-thinking ideas for the future. |
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