Bioactive polyhydroxylated sterols from the marine sponge Haliclona crassiloba
In: Steroids. ELSEVIER SCIENCE INC: New York. ISSN 0039-128X; e-ISSN 1878-5867, more
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| Keywords |
Haliclona crassiloba de Laubenfels, 1950 [WoRMS]
Marine/Coastal |
| Author keywords |
Polyhydroxylated sterols, Structure elucidation, Antibacterial activity, Haliclona crassiloba |
| Authors | | Top |
- Cheng, Z.-B.
- Xiao, H.
- Fan, C.-Q.
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- Lu, Y.-N.
- Zhang, G.
- Yin, S.
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| Abstract |
Four new polyhydroxylated sterols, named halicrasterols A–D (1–4), together with six known analogs (5–10) were isolated from the marine sponge Haliclona crassiloba. Compounds 1 and 2 represented rare examples of steroids featuring 17(20)E-double bonds. The structures of 1–10 were elucidated by spectroscopic analysis and comparison with reported data. This is the first report of a steroid profile for this species. The antimicrobial activities of 1–10 were evaluated against a panel of bacterial and fungal strains in vitro, and compounds 4 and 9 showed moderate activity against some of the Gram-positive strains with MICs ranging from 4 to 32 μg/mL. |
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