Total synthesis of μ-conotoxin lt5d
In: RSC Advances. Royal Society of Chemistry: Cambridge. e-ISSN 2046-2069, more
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| Authors | | Top |
- Naraga, A.M.B.
- Belleza, O.J.V.
- Villaraza, A.J.L.
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| Abstract |
The total synthesis of μ-conotoxin lt5d is presented for the first time employing two different strategies. One involves glutathione-assisted oxidation where all disulphide linkages are formed simultaneously. Another involves orthogonal protection of cysteine residues, allowing the controlled formation of disulphide linkages sequentially. Both methods achieve the same peptide. |
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