A new sulfated triterpene glycoside from the sea cucumber Colochirus quadrangularis, and evaluation of its antifungal, antitumor and immunomodulatory activities
Yang, W.-S.; Qi, X.-R.; Xu, Q.-Z.; Yuan, C.-H.; Yi, Y.-H.; Tang, H.-F.; Shen, L.; Han, H. (2021). A new sulfated triterpene glycoside from the sea cucumber Colochirus quadrangularis, and evaluation of its antifungal, antitumor and immunomodulatory activities. Bioorg. Med. Chem. 41: 116188. https://dx.doi.org/10.1016/j.bmc.2021.116188
In: Bioorganic & Medicinal Chemistry. Elsevier: Amsterdam. ISSN 0968-0896; e-ISSN 1464-3391, more
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| Keywords |
Colochirus quadrangularis Troschel, 1846 [WoRMS]
Marine/Coastal |
| Author keywords |
Sea cucumber, Colochirus quadrangularis, Triterpene glycoside, Coloquadranoside A, Bioactivity |
| Authors | | Top |
- Yang, W.-S.
- Qi, X.-R.
- Xu, Q.-Z.
- Yuan, C.-H.
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- Yi, Y.-H.
- Tang, H.-F.
- Shen, L.
- Han, H.
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| Abstract |
Our continuing search for marine bioactive secondary metabolites led to the screening of crude extracts of sea cucumbers by the model of Pyricularia oryzae. A new sulfated triterpene glycoside, coloquadranoside A (1), together with four known triterpene glycosides, philinopside A, B, E and pentactaside B (2–5) were isolated from the sea cucumber Colochirus quadrangularis, and their structures were elucidated using extensive spectroscope analysis (ESI-MS, 1D and 2D NMR) and chemical methods. Coloquadranoside A possesses a 16-acetyloxy group in the holostane-type triterpene aglycone with a 7(8)–double bond, a double bond (25,26) at its side chain, and two β-D-xylose in the carbohydrate chain. Coloquadranoside A exhibits in vitro some antifungus, considerable cytotoxicity (IC50 of 0.46–2.03 μM) against eight human tumor cell lines, in vivo antitumor, and immunomodulatory activity. |
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