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Cembrane diterpenoids: chemistry and pharmacological activities
Zhang, N.; Xu, W.; Yan, Y.; Chen, M.; Li, H.; Chen, L. (2023). Cembrane diterpenoids: chemistry and pharmacological activities. Phytochemistry 212: 113703. https://dx.doi.org/10.1016/j.phytochem.2023.113703
In: Phytochemistry. PERGAMON-ELSEVIER SCIENCE LTD: Oxford. ISSN 0031-9422; e-ISSN 1873-3700, more
Peer reviewed article  
Available in  Authors 
Keywords
    Marine/Coastal; Terrestrial
Authors  Top 
  • Zhang, N.
  • Xu, W.
  • Yan, Y.
  • Chen, M.
  • Li, H.
  • Chen, L.
Abstract
    Cembrane diterpenoids (cembranoids), characterized by a 14-membered carbon ring and wide variety of functional groups, found in marine and terrestrial organisms. Many studies have shown that cembrane diterpenoids have cytotoxic and anti-inflammatory activities and are widely used in the development of new drugs. This review covered publications from 2011 to 2022 and classified the cembrane-type diterpenoids into isopropyl (ene) type, γ-lactone or unsaturated five-membered ring, δ-lactone or unsaturated six-membered ring, ε-lactone or unsaturated seven-membered ring, and other cembrane diterpenes. In addition, the biological activity and structure-activity relationship were summarized. This will provide guidance for new cembrane-type diterpenes as lead compounds to explore their potential application for treating cancer and inflammatory diseases.
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