IMIS

A new integrated search interface will become available in the next phase of marineinfo.org.
For the time being, please use IMIS to search available data

 

[ report an error in this record ]basket (1): add | show Print this page
one publication added to basket [361798]
An injectable, self-healing, 3D printable, double network co-enzymatically crosslinked hydrogel using marine poly- and oligo-saccharides for wound healing application
Jafari, H.; Alimoradi, H.; Delporte, C.; Bernaerts, K.V.; Heidari, R.; Podstawczyk, D.; Niknezhad, S.V.; Shavandi, A. (2022). An injectable, self-healing, 3D printable, double network co-enzymatically crosslinked hydrogel using marine poly- and oligo-saccharides for wound healing application. Applied Materials Today 29: 101581. https://dx.doi.org/10.1016/j.apmt.2022.101581
In: Applied Materials Today. ELSEVIER SCIENCE BV: Amsterdam. ISSN 2352-9407, more
Peer reviewed article  
Available in  Authors 
Keyword
    Marine/Coastal
Author keywords
    Marine polysaccharides; Injectable hydrogels; Glucose oxidize; Enzyme mediated crosslinking; Wound healing
Authors  Top 
  • Jafari, H., more
  • Alimoradi, H.
  • Delporte, C.
  • Bernaerts, K.V.
  • Heidari, R.
  • Podstawczyk, D.
  • Niknezhad, S.V.
  • Shavandi, A., more
Abstract
    In this study, we designed dual network hydrogels with antioxidant and antibacterial activities using marine poly- and oligosaccharides with skin wound healing potential. The synergy between dual enzymatic co-crosslinking based on glucose oxidize (GOx)/horseradish peroxidase (HRP) and electrostatic interaction between positively charged chitooligosaccharides (COS) and phenolated chitosan with negatively charged phenolated alginate formed a hydrogel. The Gel-COS hydrogels exhibited toughness, self-healing, moldability, injectability, and 3D printability. Investigation of the physicochemical properties of the hydrogels exhibited a swelling ratio (< 50%) and in vitro biodegradation after 9 days. Furthermore, the hydrogels exhibited antioxidant properties and antibacterial activity against E. coli and S. aureus. The hydrogels were not cytotoxic and enhanced the migration of 3D cell encapsulated 3T3-L1 fibroblasts, blood vessel formation, as well as in vivo wound healing in a rat model. The Gel-COS hydrogel can be considered a promising skin wound dressing material.
All data in the Integrated Marine Information System (IMIS) is subject to the VLIZ privacy policy Top | Authors