Callyspongia aerizusa: a brief review of its bioactive compounds and their potential as pharmaceuticals
Alfrido, B.; Soemadiredja, C.A.; Yaxley, L.M.; Assidqi, K. (2025). Callyspongia aerizusa: a brief review of its bioactive compounds and their potential as pharmaceuticals. IOP Conference Series: Earth and Environmental Science 1564(1): 012003. https://dx.doi.org/10.1088/1755-1315/1564/1/012003
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| Keyword |
Callyspongia aerizusa Desqueyroux-Faúndez, 1984 [WoRMS]
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| Author keywords |
marine sponge; secondary metabolite; therapeutic effect |
| Authors | | Top |
- Alfrido, B.
- Soemadiredja, C.A.
- Yaxley, L.M.
- Assidqi, K.
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| Abstract |
Callyspongia aerizusa (C. aerizusa) is a marine sponge discovered in the Indo-Pacific region, with the population majority located in the eastern part of Indonesia. It is known for its rich biodiversity and ability to produce many bioactive compounds with great pharmaceutical potential. This non-systematic review comprehensively explores and focuses on the pharmaceutical activities of C. aerizusa, highlighting its anticancer, antitubercular, and antifungal activities. Several bioactive compounds that have been isolated and studied from the species, such as ergost-22-en-3-one, ergost-7-en-3-ol, callyaerin E, and callyaerin H, exhibit cytotoxic activity that has shown strong effects against the lung cancer cell line (A549) and esophageal cancer cells (TE-8), through triggering apoptosis as a programmed cell death. By activating key pathway proteins such as caspase-3, caspase-9, and PARP-1, the cells are disrupted. In addition, cyclic peptide compounds such as callyaerin E, H, and G inhibit the growth of lymphoma cells, potentially by disrupting the cell membranes and their signalling pathways. In the treatment of infectious diseases, callyaerin A has shown a promising role in exhibiting antimycobacterial activity against Mycobacterium tuberculosis, while callyaerins A, B, and E show effectiveness in exhibiting antifungal activities against Candida albicans. Furthermore, C. aerizusa also plays a role in the biodegradation of marine pollutants through the sponge mutualistic symbiosis relationship with bacteria such as Acinetobacter calcoaceticus (AC). This review summarizes the C. aerizusa and its bioactive compounds with promising values as a source of novel therapeutic agents, particularly in the development of alternative treatments for cancer and infectious diseases, showing beneficial prospects for biotechnology. |
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