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TRPV1 as a key determinant in ciguatera and neurotoxic shellfish poisoning
Cuypers, E.; Yanagihara, A.; Rainier, J.D.; Tytgat, J. (2007). TRPV1 as a key determinant in ciguatera and neurotoxic shellfish poisoning. Biochem. Biophys. Res. Commun. 361(1): 214-217. dx.doi.org/10.1016/j.bbrc.2007.07.009
In: Biochemical and Biophysical Research Communications. ACADEMIC PRESS INC ELSEVIER SCIENCE: San Diego etc.. ISSN 0006-291X; e-ISSN 1090-2104, more
Peer reviewed article  
Available in  Authors 
Keywords
    Diseases > Human diseases > Ciguatera
    Diseases > Human diseases > Paralytic shellfish poisoning
    Marine/Coastal
Author keywords
    TRPV1; gambierol; brevetoxin; ciguatera fish poisoning; neurotoxicshellfish poisoning
Authors  Top 
  • Cuypers, E., more
  • Yanagihara, A.
  • Rainier, J.D.
  • Tytgat, J., more
Abstract
    Ciguatera fish poisoning and neurotoxic shellfish poisoning are distinct clinical entities characterized by gastrointestinal and neurological disturbances, following the consumption of certain reef fish and shellfish containing toxic polyether compounds sporadically present in certain toxic marine dinoflagellates. The biotransformation and bioaccumulation of gambierol and brevetoxin, and their congeners, are believed to be involved in the pathogenesis of these "food-chain diseases", for which no effective treatments are available. Here, we describe for the first time the potent effect of gambierol and brevetoxin on TRPV1 channels, a key player in thermal and pain sensation. Our findings may lead to promising new therapeutic interventions.
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