Skip to main content

IMIS

A new integrated search interface will become available in the next phase of marineinfo.org.
For the time being, please use IMIS to search available data

 

[ report an error in this record ]basket (0): add | show Print this page

Urbilaterian origin of paralogous GnRH and corazonin neuropeptide signalling pathways
Tian, S.; Zandawala, M.; Beets, I.; Baytemur, E.; Slade, S.E.; Scrivens, J.H.; Elphick, M.R. (2016). Urbilaterian origin of paralogous GnRH and corazonin neuropeptide signalling pathways. NPG Scientific Reports 6: 28788. https://dx.doi.org/10.1038/srep28788
In: Scientific Reports (Nature Publishing Group). Nature Publishing Group: London. ISSN 2045-2322; e-ISSN 2045-2322, more
Peer reviewed article  

Available in  Authors 

Keyword
    Marine/Coastal

Authors  Top 
  • Tian, S.
  • Zandawala, M.
  • Beets, I., more
  • Baytemur, E.
  • Slade, S.E.
  • Scrivens, J.H.
  • Elphick, M.R.

Abstract
    Gonadotropin-releasing hormone (GnRH) is a key regulator of reproductive maturation in humans and other vertebrates. Homologs of GnRH and its cognate receptor have been identified in invertebrates–for example, the adipokinetic hormone (AKH) and corazonin (CRZ) neuropeptide pathways in arthropods. However, the precise evolutionary relationships and origins of these signalling systems remain unknown. Here we have addressed this issue with the first identification of both GnRH-type and CRZ-type signalling systems in a deuterostome–the echinoderm (starfish) Asterias rubens. We have identified a GnRH-like neuropeptide (pQIHYKNPGWGPG-NH2) that specifically activates an A. rubens GnRH-type receptor and a novel neuropeptide (HNTFTMGGQNRWKAG-NH2) that specifically activates an A. rubens CRZ-type receptor. With the discovery of these ligand-receptor pairs, we demonstrate that the vertebrate/deuterostomian GnRH-type and the protostomian AKH systems are orthologous and the origin of a paralogous CRZ-type signalling system can be traced to the common ancestor of the Bilateria (Urbilateria).

All data in the Integrated Marine Information System (IMIS) is subject to the VLIZ privacy policy Top | Authors