Evaluating the use of a high-resolution time-of-flight mass spectrometer for the determination of selected environmental contaminants
Roose, P. (2005). Evaluating the use of a high-resolution time-of-flight mass spectrometer for the determination of selected environmental contaminants, in: Roose, P. Volatile organic compounds and related microcontaminants in the Scheldt estuary and the southern North Sea: method development and monitoring. pp. 125-140 In: Roose, P. (2005). Volatile organic compounds and related microcontaminants in the Scheldt estuary and the southern North Sea: method development and monitoring. PhD Thesis. Vrije Universiteit Amsterdam: Amsterdam. 254 pp., more Related to:Dallüge, J.; Roose, P.; Brinkman, U.A.Th. (2002). Evaluating the use of a high-resolution time-of-flight mass spectrometer for the determination of selected environmental contaminants. J. Chromatogr. 970(1-2): 213-223. https://dx.doi.org/10.1016/S0021-9673(02)00233-9, more |  |
| Abstract | A benchtop high-resolution time-of-flight mass spectrometer (TOF MS) was evaluated for the determination of key organic microcontaminants. The major advantage of the TOF MS proved to be the high mass resolution of about 0.002 Da (10 ppm). Consequently, the detectability of polar pesticides, polycyclic aromatic hydrocarbons and polychlorinated biphenyls is excellent, and detection limits are in the order of 1-4 pg injected mass. Best mass spectral resolution was obtained for medium-scale peaks. It is a disadvantage that the calibration range is rather limited, viz. to about two orders of magnitude. The high mass spectral resolution was especially useful to improve the selectivity and sensitivity when analyzing target compounds in complex samples and to prevent false-positive identifications. |
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